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Arrhythmias & electrophysiologyMechanistic study

Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging

EuropacePublished

  • Mechanistic study
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Authors' conclusion

Activation and recovery patterns vary profoundly between normal subjects, but are stable individually beat to beat, with a male preponderance to shorter recovery.

Study context

Population
Normal human subjects (age 49 ± 14 years, 6/22 male) and subjects with bundle branch block (BBB) or long-QT syndrome (LQTS), assessed by noninvasive ECG imaging (electrocardiographic imaging (ECGI))
Participants
22 / 4 / 4
Comparison
Normal vs BBB vs LQTS
  • Normaln = 22reference
  • BBBn = 4
  • LQTSn = 4

Main finding

As reported in the abstract

Epicardial activation and recovery patterns by ECGI
Median Pearson correlation coefficient (CC), between-subject: ECG signals
0.61
Median Pearson CC, between-subject: activation patterns
0.32
Median Pearson CC, between-subject: recovery patterns
0.19
CC, within-subject beat-to-beat: ECG signals
0.98
CC, within-subject beat-to-beat: activation patterns
0.89
CC, within-subject beat-to-beat: recovery patterns
0.82

Further findings

Activation and/or recovery patterns in BBB or LQTS

Contrasted significantly with the normal population

Original publication

Variant patterns of electrical activation and recovery in normal human hearts revealed by noninvasive electrocardiographic imaging. Europace. Published 5 July 2024. doi:10.1093/europace/euae172
Read the original article ↗PubMedCite RIS · BibTeX

Summarised from the published abstract; every number is checked against it