Variations in remnant cholesterol and the risk of cardiovascular disease: a national longitudinal cohort study
Authors' conclusion
Longitudinal RC increases were associated with higher CVD risks, while RC reductions were associated with decreased risks.
Study context
- Population
- Middle-aged and older adults in the China Health and Retirement Longitudinal Study (CHARLS)
- Participants
- 3,866 participants
- Exposure
- Changes in remnant cholesterol between Waves 1 and 3 and incident cardiovascular disease (CVD)
- Outcome
- Incident CVD
- Follow-up
- 5.0 years
Methodological detailsnational longitudinal cohort
- National longitudinal cohort
Main finding
As reported in the abstract
Incident CVD by RC change pattern
Each group vs consistently high RCHazard ratio (95% CI)
High to low RC
0.71(0.54–0.94)
Low to high RCsimilar risk
0.85(0.68–1.06)
Observational data: associations, not effects.
Further findings
Incident CVD, highest tertile cumulative remnant cholesterol (RC)
| Comparison | HR (95% CI) | |
|---|---|---|
| Highest tertile cumulative RC | 1.37 (1.11–1.69) | |
| 0.512Hazard ratio (log scale) |
Incident CVD, lowest ΔRC tertile (high baseline RC subgroup)
| Comparison | HR (95% CI) | |
|---|---|---|
| Lowest ΔRC tertile | 0.68 (0.52–0.89) | |
| 0.512Hazard ratio (log scale) |
Original publication
Variations in remnant cholesterol and the risk of cardiovascular disease: a national longitudinal cohort study. Eur J Prev Cardiol. Published 22 September 2025. doi:10.
Summarised from the published abstract; every number is checked against it