Heart failure & cardiomyopathies
Varying effect of atrial fibrillation ablation in patients with heart failure with preserved ejection fraction according to CHA2DS2-VASc score
Authors' conclusion
RFCA for AF is associated with reduced AF recurrence and improved cardiovascular outcomes in patients with HFpEF. However, these benefits may be limited for patients with a CHA2DS2-VASc score >4 (high comorbidity burden).
Study context
- Population
- Atrial fibrillation (AF) patients with heart failure and preserved ejection fraction (HFpEF) from the China-AF cohort, recruited August 2011–December 2020median follow-up 65.9 months
- Participants
- 1,700 patients
- Exposure
- Radiofrequency catheter ablation (RFCA) vs no RFCA, by comorbidity burden
- Outcome
- Composite of:
- CV death and ischemic stroke/TIA
- All-cause death
- Follow-up
- Median 65.9 months
Main finding
As reported in the abstract
RFCA vs Without RFCAAdjusted hazard ratio (95% CI)
Low comorbidity burden (score ≤4): composite events
0.35(0.21–0.59)
Low comorbidity burden (score ≤4): all-cause death
0.31(0.17–0.54)
- Interaction between comorbidity burden and RFCA for CV death
- P for interaction = 0.045
- Interaction between comorbidity burden and RFCA for ischemic stroke/TIA
- P for interaction = 0.010
Observational data: associations, not effects.
Further findings
- RFCA associated with reduced risk of AF recurrence in both comorbidity burden groups
Original publication
Varying effect of atrial fibrillation ablation in patients with heart failure with preserved ejection fraction according to CHA2DS2-VASc score. Heart Rhythm. Published 19 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →