Cardiometabolic & kidneyCohort study
Vascular Regenerative Cell Deficiencies in South Asian Adults
- Prospective observational study
Authors' conclusion
South Asian people with cardiometabolic disease had less vascular regenerative and reparative cells suggesting compromised vessel repair capabilities that may contribute to the excess vascular risk in this population.
Study context
- Population
- Adults with documented CVD or established DM with ≥1 other CV risk factor
- Participants
- 60 vs 60
- Exposure
- South Asian vs White European adults
- South Asiann = 60
- White Europeann = 60reference
- Outcome
- Difference in frequency of circulating ALDHhi progenitor cells, monocytes and granulocytes between groups
Main finding
As reported in the abstract
Lower circulating pro-angiogenic ALDHhiSSClowCD133+ progenitor cells in South Asian
P < 0.001
Lower ALDHhiSSCmidCD14+CD163+ monocytes with vessel-reparative capacity in South Asian
P < 0.001
Proportionally more ALDHhi progenitor cells with high reactive oxygen species content in South Asian
P < 0.05
Observational data: associations, not effects.
Further findings
ALDHhiSSClowCD133+ cell count, adjusted for sex, age, BMI and glycated hemoglobin
- South Asian ethnicity independently associated with lower count
Original publication
Summarised from the published abstract; every number is checked against it