Cohort study
Vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing
- Histopathological registry study
- autopsy registry
Authors' conclusion
Severe calcification, especially surface calcified area is an independent predictor of uncovered struts and delayed healing after newer-generation DES implantation.
Study context
- Population
- Newer-generation drug-eluting stents (DES) (Xience, Resolute-Integrity, PROMUS-Element, Synergy) with implant duration ≥30 days, histologically analysedDES from registry of 1211 stents
- Participants
- 134 participants
- Exposure
- Severely calcified vs non-severely calcified stented lesions
- SCn = 46
- NCn = 88reference
Main finding
As reported in the abstract
Percent-uncovered struts per section
P = 0.02
Observational data: associations, not effects.
Further findings
Severe medial tears
P = 0.03
≥3 consecutive struts in contact with surface calcified area (3SC)
P < 0.0001
Neoatherosclerosis
P = 0.02
Independent predictors of uncovered struts (multivariate)
- Implant duration ≤6 months, OR
- 7.7 (P < 0.0001)
- 3SC, OR
- 6.5 (P < 0.0001)
- Strut malapposition, OR
- 5.0 (P < 0.0001)
- Lack of medial tears, OR
- 2.5 (P = 0.0005)
Original publication
Vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing. Eur Heart J. Published 5 December 2019. doi:10.1093/eurheartj/ehz850
Summarised from the published abstract; every number is checked against it