Arrhythmias & electrophysiologyCohort study
Vasovagal Responses to Human Monomorphic Ventricular Tachycardia
- Retrospective cohort study with prospective cohort
- retrospective analysis
Authors' conclusion
Nearly one-half of VT episodes are associated with failure to augment SR, indicative of an under-recognized pathophysiological vasovagal response to VT. Inappropriate SR responses were more predictive of hemodynamic instability than VT rate and ejection fraction.
Study context
- Population
- Patients undergoing scar-related ventricular tachycardia (VT) ablation
- Participants
- 150 patients · 261 VT episodes
- Exposure
- Sinus rate responses during VT; atropine in prospective cohort
Main finding
As reported in the abstract
Untolerated VT by SR response
- Difference between groups
- P < 0.001
- Sinus rate (SR) response: sympathetic
- 52%
- SR response: unchanged
- 31%
- SR response: vagal
- 17%
Observational data: associations, not effects.
Further findings
Inappropriate SR response, untolerated vs tolerated VT
P < 0.001
Improved hemodynamic tolerance to VT with atropine (prospective cohort)
- Improved tolerance
- 70%
- prospective cohort n = 30
Original publication
Vasovagal Responses to Human Monomorphic Ventricular Tachycardia. J Am Coll Cardiol. Published 12 September 2023. doi:10.1016/j.jacc.2023.06.033
Summarised from the published abstract; every number is checked against it