Arrhythmias & electrophysiology
Vasovagal Responses to Human Monomorphic Ventricular Tachycardia: Hemodynamic Implications From Sinus Rate Analysis
Authors' conclusion
Nearly one-half of VT episodes are associated with failure to augment SR, indicative of an under-recognized pathophysiological vasovagal response to VT. Inappropriate SR responses were more predictive of hemodynamic instability than VT rate and ejection fraction.
Study context
- Population
- Patients undergoing scar-related ventricular tachycardia (VT) ablation
- Participants
- 150 patients261 VT episodes
- Exposure
- Sinus rate responses during VT; atropine in prospective cohort
- Outcome
- Untolerated VT by SR response
Methodological detailsretrospective analysis
- Retrospective analysis
Main finding
As reported in the abstract
- Difference between groups
- P < 0.001
- Sinus rate (SR) response: sympathetic
- 52%
- SR response: unchanged
- 31%
- SR response: vagal
- 17%
Observational data: associations, not effects.
Further findings
Inappropriate SR response, untolerated vs tolerated VT
P < 0.001
Improved hemodynamic tolerance to VT with atropine (prospective cohort)
- Improved tolerance
- 70%
- Prospective cohort n = 30
Original publication
Vasovagal Responses to Human Monomorphic Ventricular Tachycardia: Hemodynamic Implications From Sinus Rate Analysis. J Am Coll Cardiol. Published 12 September 2023. doi:10.
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