Pulmonary vascular disease & thromboembolismCohort study
Venous thromboembolism in 5-year cancer survivors: a nationwide cohort study
- Nationwide matched cohort study
- Danish nationwide registries
Authors' conclusion
Five-year cancer survivors had a higher associated rate of VTE compared with the background population.
Study context
- Population
- Adults (≥18 years) diagnosed with cancer 2000–2017, included 5 years after diagnosis (2005–2022), Denmark
- Participants
- 222,297 vs 222,297
- Exposure
- 5-year cancer survivors vs matched background population
- Cancer survivorsn = 222,297
- Background populationn = 222,297reference
- Outcome
- VTE
- Follow-up
- Median 5.6 years
Main finding
As reported in the abstract
Adjusted hazard ratio
1.85
95% CI 1.78–1.93
Cancer survivors vs Background population
aHR 1.85 (95% CI 1.78–1.93)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| VTE by age (subgroup) — <50 years vs Background population · cancer survivors vs background population | 2.85 (2.33–3.47) | |
| VTE by age (subgroup) — 50-64 years vs Background population · cancer survivors vs background population | 2.26 (2.07–2.46) | |
| VTE by age (subgroup) — ≥65 years vs Background population · cancer survivors vs background population | 1.69 (1.61–1.77) | |
| VTE by sex (subgroup) — Females vs Background population · cancer survivors vs background population | 1.84 (1.75–1.95) | |
| VTE by sex (subgroup) — Males vs Background population · cancer survivors vs background population | 1.86 (1.75–1.98) | |
| 0.20.5125Adjusted hazard ratio (log scale) |
- Venous thromboembolism (VTE) by age (subgroup): Pinteraction<0.0001
- VTE by sex (subgroup): Pinteraction=0.94
VTE by cancer subtype
- Survivors of all 21 cancer subtypes had a higher rate of VTE vs background population; highest incidence rates for multiple myeloma
VTE by age (subgroup)
- HRs higher in younger vs older cancer survivors
VTE by sex (subgroup)
- Similar HRs in females and males
Original publication
Venous thromboembolism in 5-year cancer survivors: a nationwide cohort study. Eur J Prev Cardiol. Published 29 August 2026. doi:10.1093/eurjpc/zwag439
Summarised from the published abstract; every number is checked against it