Arrhythmias & electrophysiology
Venous Thromboembolism in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis of 4,170,027 Patients
Authors' conclusion
The risk of VTE is highest in the first 3 to 6 months after AF diagnosis and decreases over time.
Study context
- Population
- Patients with and without atrial fibrillation (AF) in observational studies
- Participants
- 4,170,027 patients8 studies
- Comparison
- AF vs no AF, by time from AF diagnosis
- AFn = 650,828
- Outcome
- Risk of venous thromboembolism (VTE), deep vein thrombosis (DVT) and pulmonary embolism (PE) by time from AF onset: short (≤3 months), medium (≤6 months), long (>6 months)
Pooled result
As reported in the abstract
VTE, DVT and PE by time from AF diagnosis
AF vs No AFHazard ratio (95% CI)
PE, short-term (≤3 months); I2 = 0%
9.62(7.07–13.09)
DVT, short-term (≤3 months); I2 = 0%
6.18(4.51–8.49)
VTE, up to 6 months; I2 = 79%
3.69(1.65–8.27)
DVT, up to 6 months; I2 = 0%
1.75(1.43–2.14)
PE, up to 6 months; I2 = 68%
4.3(1.61–11.47)
Long-term (>6 months), outcome not named in abstract; I2 = 72%
1.39(1.00–1.92)
PE, long-term (>6 months); I2 = 0%
1.08(1.00–1.16)
Original publication
Venous Thromboembolism in Patients With Atrial Fibrillation: A Systematic Review and Meta-Analysis of 4,170,027 Patients. JACC Adv. Published 16 August 2023. doi:10.
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