Acute cardiac care & resuscitationCohort study
Ventilation parameters during Advanced Life Support in cardiac arrest (CAvent): A multicentre observational cohort study
- multicentre, prospective observational cohort study
- five Advanced Life Support systems in Sweden and the Netherlands
- mixed-effects regression models
Authors' conclusion
Ventilation parameters during CPR vary substantially across manual ventilation modes and airway modalities. Specifically, BVM ventilations demonstrate limited efficacy, SAD ventilations yield consistent tidal volumes and pressures across modes, with leakage increasing over time, while asynchronous ETT ventilation generates high airway pressures. This highlights a need for standard measurement of ventilation parameters in CPR-related studies and clinical practice.
Study context
- Population
- Adult patients with cardiac arrest receiving CPR with manual ventilationcardiac arrest patients yielding 28,120 ventilations for analysis
- Participants
- 241 patients
- Exposure
- Parameters were compared between ventilation modes (synchronous versus asynchronous) and airway modalities (bag-valve-mask (BVM), supraglottic airway device (SAD), and endotracheal tube (ETT))
Main finding
As reported in the abstract
Expiratory tidal volume
Observational data: associations, not effects.
Further findings
| Outcome | synchronous BVM | synchronous SAD | asynchronous SAD | asynchronous ETT |
|---|---|---|---|---|
| Time of airway pressure >30 cmH2O | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | 5.8 (95% CI 5.1–6.4) s·min-1 |
| Peak inspiratory pressure | Not reported in the abstract | Not reported in the abstract | Not reported in the abstract | 51.0 (95% CI 48.7–53.1) cmH2O |
Time of airway pressure >30 cmH2O
- Longest with asynchronous ETT ventilation
Peak inspiratory pressure
- Highest with asynchronous ETT ventilation
Original publication
Ventilation parameters during Advanced Life Support in cardiac arrest (CAvent): A multicentre observational cohort study. Resuscitation. Published 14 July 2026. doi:10.1016/j.resuscitation.2026.111203
Summarised from the published abstract; every number is checked against it