Valvular & structural heart diseaseCohort study
Ventricular Arrhythmias After Self-Expanding Transcatheter Pulmonary Valve Replacement
- multicenter SERVE registry
Authors' conclusion
This large multicenter registry study of the natural history of VA after SETPV implantation showed VA to be frequent during the procedural admission, with Alterra patients having more VA than Harmony patients. VA burden decreased to lower than baseline at 6 months in Harmony patients and to baseline in Alterra patients.
Study context
- Population
- Patients with a native or surgically repaired right ventricular outflow tract undergoing self-expanding transcatheter pulmonary valve implantation at 25 U.S. centersHarmony 359 · Alterra 154
- Participants
- 513 SETPV implants
- Exposure
- Alterra vs Harmony
- Alterran = 154
- Harmonyn = 359
Main finding
As reported in the abstract
VA during the procedural admission · procedural admission
P = 0.014
Observational data: associations, not effects.
Further findings
| Outcome | Harmony | Alterra |
|---|---|---|
| Predicted probability of VA burden vs baseline · 6 months | change from baseline −6% (95% CI −10%–-2%) | |
| P | P < 0.001 | P = 0.53 |
- Predicted probability of VA burden vs baseline: decreased below baseline for Harmony; to baseline for Alterra
Baseline characteristics
- Median age
- 28 years (Q1-Q3: 17-44 years)
- No difference in baseline VA by valve type
Original publication
Ventricular Arrhythmias After Self-Expanding Transcatheter Pulmonary Valve Replacement. JACC Clin Electrophysiol. doi:10.1016/j.jacep.2026.02.007
Summarised from the published abstract; every number is checked against it