Arrhythmias & electrophysiology
Ventricular arrhythmias during exercise testing in pediatric patients with arrhythmogenic cardiomyopathy at first presentation and with different ventricular involvement
Authors' conclusion
The behavior of VAs during ET at the beginning of ACM is highly variable, and suppression during exercise is not uncommon. Nevertheless, presence at the peak of exercise is more common in ACM patients. Baseline left bundle branch block-superior axis PVCs and VAs during recovery correlate with the presence of ACM. VA morphology and ET behavior cannot predict ACM phenotype. Polymorphism and nonsustained ventricular tachycardias are more prevalent in patients with BIV-ACM.
Study context
- Population
- Pediatric patients diagnosed with definite arrhythmogenic cardiomyopathy (ACM)
- Comparison
- ACM vs control group; Biventricular ACM (BIV-ACM) vs non-biventricular ACM
- Outcome
- VAs at baseline
- Follow-up
- Baseline
Main finding
As reported in the abstract
| Group | Value | Nonsustained ventricular tachycardia | Isolated PVCs |
|---|---|---|---|
| ACM | 80% | 3 | 17 |
ACM
Value80%
Nonsustained ventricular tachycardia3
Isolated PVCs17
Further findings
| Outcome | ACM | Control group | BIV-ACM |
|---|---|---|---|
| VAs at peak exercise | 40% | 10% | — not stated in the abstract |
| VAs during recovery | 68% | 8% | — not stated in the abstract |
| Irregular VAs | — not stated in the abstract | — not stated in the abstract | 80% |
— not stated in the abstract
- Polymorphism and nonsustained ventricular tachycardias during recovery · BIV-ACM vs non-biventricular ACM · more prevalent in BIV-ACM
- P = 0.03; P = .03
Association with probability of having ACM (vs controls)
- PVCs with left bundle branch block-superior axis at baseline
- P = 0.0038
- Ventricular arrhythmias (VAs) during recovery
- P < 0.0001
Original publication
Ventricular arrhythmias during exercise testing in pediatric patients with arrhythmogenic cardiomyopathy at first presentation and with different ventricular involvement. Heart Rhythm. Published 26 March 2025. doi:10.
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