Arrhythmias & electrophysiologyCohort study
Ventricular conduction is a marker for arrhythmic risk in SCN5A- E1784K overlap sodium channel disease
- Retrospective cohort study
- multicentre
- observational
Authors' conclusion
Ventricular myocardial conduction appears likely to play a role in the risk of arrhythmic events in patients with SCN5A-E1784K.
Study context
- Population
- Subjects with SCN5A-E1784K (LQTS/Brugada syndromes (BrS) overlap sodium channel disease) from Europe, US and Japan
- Participants
- 231 subjects
- Outcome
- Lethal events (sudden death, non-fatal cardiac arrest, documented sustained VT or VF) and cardiac events (arrhythmic syncope plus any lethal event)
Main finding
As reported in the abstract
Lethal event
14 (6%)
Cardiac event
45 (19%)
Observational data: associations, not effects.
Original publication
Ventricular conduction is a marker for arrhythmic risk in SCN5A- E1784K overlap sodium channel disease. Europace. Published 11 May 2026. doi:10.1093/europace/euag113
Summarised from the published abstract; every number is checked against it