Congenital heart diseaseCohort study
Ventricular septal defect characteristics influence presence of septal anatomical isthmuses in patients with repaired tetralogy of Fallot
- Retrospective cohort study
- consecutive patients
Authors' conclusion
Ventricular septal defect characteristics aid in determining the presence of septal AIs potentially related to VT. In patients with doubly committed VSDs, septal VT substrates are unlikely.
Study context
- Population
- Patients with repaired tetralogy of Fallot who underwent electroanatomical mapping, 2005–2023, with surgical report of ventricular septal defect (VSD) details
- Participants
- 91 patients
- Exposure
- Septal anatomical isthmuses by VSD type
- Outlet perimembranous VSDn = 76
- Outlet muscular VSDn = 6
- Doubly committed juxta-arterial VSDn = 7
- Outcome
- Presence of septal anatomical isthmuses AI 3 (VSD–pulmonary annulus) and AI 4 (VSD–tricuspid annulus)
Main finding
As reported in the abstract
Presence of AI 3 and AI 4
| Group | Anatomical isthmuses (AI) 3 | AI 4 | AI 4, muscular postero-inferior rim | AI 4, fibrous postero-inferior rim |
|---|---|---|---|---|
| Outlet perimembranous VSD | 97% | 0 | ||
| Outlet muscular VSD | 83% | 33% | ||
| Doubly committed juxta-arterial VSD | 0 | 50% | 0 |
Observational data: associations, not effects.
Original publication
Ventricular septal defect characteristics influence presence of septal anatomical isthmuses in patients with repaired tetralogy of Fallot. Europace. Published 16 December 2024. doi:10.1093/europace/euae283
Summarised from the published abstract; every number is checked against it