Heart failure & cardiomyopathiesCohort study
Ventricular Strain Predicts the Risk of Right Heart Failure After Durable Left Ventricular Assist Device Implantation
- retrospective imaging analysis
- multivariable logistic regression models
Authors' conclusion
RVFW strain and coupling indexes derived from catheterization and echocardiographic RV strain imaging can aid with the need for an RVAD and RHF risk stratification following LVAD implantation.
Study context
- Population
- Patients undergoing durable left ventricular assist device (LVAD) implantation
- Participants
- 288 patients
- Exposure
- RV pulmonary artery (RVPA) coupling indexes fused from right ventricle free-wall (RVFW) strain or right ventricle global longitudinal strain (RVGLS) with systolic pulmonary artery pressure (sPAP), and standard hemodynamics, to predict the need for an RV assist device (RVAD) and right heart failure (RHF)
Main finding
As reported in the abstract
RHF
Developed RHF
Eighty-two patients (28.5%)
Observational data: associations, not effects.
Further findings
Association of reduced right ventricle (RV) strain with the need for an RVAD
| Comparison | OR (95% CI) | P value | |
|---|---|---|---|
| Reduced RVFW strain | 1.37 (1.23–1.55) | P < 0.001 | |
| Reduced RVGLS strain | 1.55 (1.34–1.83) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | P value |
|---|---|---|
| Association of RVPA coupling with the need for an RVAD — RVFW/sPAP | 0.03-4 (0.03-6 to 0.01-2) | P < 0.001 |
| Association of RVPA coupling with the need for an RVAD — RVGLS/sPAP | 0.09-6 (0.01-9 to 0.06-4) | P < 0.001 |
Temporary RVAD required
- Required a temporary RVAD
- 52 (18.1%)
Multivariable model with the highest predictive accuracy (RVFW strain and pulmonary artery pulsatility index)
- area under the curve
- 0.850
- sensitivity
- 88.6%
- specificity
- 71.3%
Original publication
Ventricular Strain Predicts the Risk of Right Heart Failure After Durable Left Ventricular Assist Device Implantation. JACC Adv. Published 17 September 2026. doi:10.1016/j.jacadv.2026.103240
Summarised from the published abstract; every number is checked against it