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Heart failure & cardiomyopathiesRandomised controlled trial

Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial

LancetPublished

  • Randomised controlled trial
  • double-blind
  • placebo-controlled
  • phase 3
  • multicentre (482 sites, 36 countries)
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Authors' conclusion

Among patients with HFrEF and no recent worsening, vericiguat did not reduce the risk of a composite endpoint of time to cardiovascular death or heart failure hospitalisation. Fewer cardiovascular deaths were observed in the vericiguat group than in the placebo group.

Study context

Population
Adults with heart failure and reduced ejection fraction (HFrEF) (LVEF ≤40%) without HF hospitalisation within 6 months or outpatient IV diuretic use within 3 months
Participants
6,105 adults
Comparison
Vericiguat vs placebo
  • Vericiguatn = 3,053
  • Placebon = 3,052reference
Primary endpoint
Time to CV death or HF hospitalisation
Follow-up
Median 18.5 months

Primary result

As reported in the abstract

Hazard ratio

0.93

95% CI 0.83–1.04

P = 0.22

Events by treatment group

Vericiguat vs Placebo
HR 0.93 (95% CI 0.83–1.04); P = 0.22

Further findings

OutcomeVericiguatPlaceboHR (95% CI)
CV death · nominal (primary endpoint not significant)9.6%11.3%0.83 (0.71–0.97)
HF hospitalisation · nominal (primary endpoint not significant)11.4%11.9%0.95 (0.82–1.10)
All-cause death · nominal (primary endpoint not significant)12.3%14.4%0.84 (0.74–0.97)

Safety

Serious adverse events

Symptomatic hypotension (most common AE)

  • Serious adverse events: safety population: 3049 per group

Original publication

Vericiguat in patients with chronic heart failure and reduced ejection fraction (VICTOR): a double-blind, placebo-controlled, randomised, phase 3 trial. Lancet. Published 30 August 2025. doi:10.1016/s0140-6736(25)01665-4
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Summarised from the published abstract; every number is checked against it