Arrhythmias & electrophysiologyRandomised controlled trial
Very high-power short-duration using 70W and a flexible tip ablation catheter for pulmonary vein isolation: the POWER PULSE randomized controlled trial
- Randomised controlled trial
Authors' conclusion
Very high-power short-duration with 70 W/5-7 s was non-superior to standard ablation regarding acute PV reconnection and 12-month freedom from any atrial arrhythmia.
Study context
- Population
- Patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein isolationrandomised 1:1
- Participants
- 200 patients
- Comparison
- vHPSD-70W vs standard ablation for pulmonary vein isolation (PVI)
- Primary endpoint
- Number of reconnected pulmonary veins (rPV) after adenosine testing
Primary result
As reported in the abstract
Number of rPVs
vHPSD-70W
0.6
mean · SD 0.8
Standard
0.8
mean · SD 0.9
P = 0.145
Secondary outcomes
Bilateral first-pass isolation
P = 0.072
First-pass isolation of left PVs
P = 0.042
Freedom from any atrial arrhythmia · 12 months
P = 0.171
Atrial tachycardia recurrence · 12 months
P = 0.005
Procedure duration
P < 0.001
Radiofrequency duration
P < 0.001
Safety
Silent cerebral lesions (SCLs)
- SCLs, vHPSD-70W vs standard
- 1/25 (4.0%) vs. 3/22 (13.6%)
- P = 0.328
Original publication
Very high-power short-duration using 70W and a flexible tip ablation catheter for pulmonary vein isolation: the POWER PULSE randomized controlled trial. Europace. Published 21 July 2025. doi:10.1093/europace/euaf105
Summarised from the published abstract; every number is checked against it