Heart failure & cardiomyopathiesCohort study
Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy
- Retrospective cohort study
- computational modelling (CircAdapt digital twin)
Authors' conclusion
Our results suggest that the reduction of septal-to-lateral work imbalance by virtual pacing in the DT can predict real-world post-CRT LV reverse remodelling.
Study context
- Population
- Heart failure (HF) patients with wide QRS (≥130 ms) and reduced LVEF (≤35%) receiving cardiac resynchronization therapy (CRT)
- Participants
- 45 patients
- Outcome
- Correlation of virtual pacing-induced changes in the digital twin with real-world left ventricular (LV) end-systolic volume change (ΔLVESV)
- Follow-up
- 6 months
Main finding
As reported in the abstract
Correlation with ΔLVESV
Baseline MWLW-S,digital twin (DT) vs ΔLVESV
r = −0.60, P < 0.001
Virtual pacing-induced ΔMWLW-S,DT vs ΔLVESV
r = 0.62, P < 0.001
ΔdP/dtmax,DT vs ΔLVESV (considerably weaker)
r = −0.34, P = 0.02
Observational data: associations, not effects.
Original publication
Virtual pacing of a patient’s digital twin to predict left ventricular reverse remodelling after cardiac resynchronization therapy. Europace. Published 30 January 2024. doi:10.1093/europace/euae009
Summarised from the published abstract; every number is checked against it