HypertensionMeta-analysis
Visit-to-visit blood pressure variability and outcome: a traditional and a dose–response meta-analysis
- Systematic review and dose–response meta-analysis
- restricted cubic spline meta-regression
Authors' conclusion
This meta-analysis shows a non-linear dose-response relationship between VVBPV and outcomes, with distinct threshold values.
Study context
- Population
- Studies of visit-to-visit BP variability (visit-to-visit BPV (VVBPV)) and mortality or fatal and non-fatal CV events
- Participants
- 10,624,740 participants · 50 studies
- Outcome
- Shape of the relationship between VVBPV and mortality or fatal and non-fatal CV events (threshold values)
Pooled result
As reported in the abstract
VVBPV thresholds above which mortality risk increases significantly
Systolic VVBPV SD threshold, all-cause mortality
11.8 mmHg
Systolic VVBPV SD threshold, CV mortality
12.1 mmHg
Diastolic VVBPV SD threshold, all-cause mortality
5.8 mmHg
Diastolic VVBPV SD threshold, CV mortality
5.25 mmHg
Further pooled results
Number of visits to assess VVBPV
- Minimum of three visits required to reliably assess the prognostic value of VVBPV
- 3
Original publication
Visit-to-visit blood pressure variability and outcome: a traditional and a dose–response meta-analysis. Eur J Prev Cardiol. Published 9 June 2026. doi:10.1093/eurjpc/zwag305
Summarised from the published abstract; every number is checked against it