Valvular & structural heart disease

Outcomes of Combined Left Atrial Appendage Occlusion and Transcatheter Mitral Edge-to-Edge Repair: The WATCH-TEER Study

JACC AdvPublished prospective multicenter registry

Authors' conclusion

Combining LAAO with MTEER is feasible in patients who have a clinical indication for both procedures.

Study context

Population
Patients with an approved clinical indication for both mitral transcatheter edge-to-edge repair (MTEER) with MitraClip and left atrial appendage occlusion (LAAO) with WATCHMAN-FLXincluded between October 2020 and March 2024
Participants
24 patients
Outcome
Composite of:
  • All-cause mortality
  • Stroke
  • Life-threatening
  • Major bleeding
Follow-up
45 days

Main finding

As reported in the abstract

Combined LAAO and MTEER

21%

5/24 of 24

All events occurred after discharge: cardiac death
1
Ischemic stroke
1
Trauma-related intracranial hemorrhage
1
Nonprocedural major bleeds
2

Observational data: associations, not effects.

Further findings

Baseline characteristics

Mean age
79.5 ± 6.3 years
Males
83%
Society of Thoracic Surgeons operative risk score
11.8% ± 5.3%
CHA2DS2-VASc score
4.5 ± 1.1
HAS-BLED score
3.3 ± 1.5

Total procedure time

Total procedure time
103.6 ± 33.7 minutes

Mitral regurgitation and NYHA functional class · 45 days

≤2+ mitral regurgitation
68%
NYHA functional class I-II symptoms
72%

Not on anticoagulation · 45 days

Not on anticoagulation at 45 days
71%
Not on anticoagulation at baseline
20%

Original publication

Outcomes of Combined Left Atrial Appendage Occlusion and Transcatheter Mitral Edge-to-Edge Repair: The WATCH-TEER Study. JACC Adv. Published 8 January 2025. doi:10.1016/j.jacadv.2024.101541

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