Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis

doi:10.1093/eurheartj/ehae406

Valvular & structural heart diseaseCohort study

Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis

Eur Heart JPublished 2 Jul 2024

Prospective cohort study
UK Biobank
accelerometer-derived exposure
dose-response analysis

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Authors' conclusion

Higher MVPA volume was associated with a lower risk of developing AS and subsequent AS-related intervention or mortality.

Study context

Population: Middle-aged UK Biobank participants with a full week of accelerometer-derived moderate to vigorous physical activity (MVPA) data, 2013–2015questionnaire cohort n = 361,681
Participants: 87,248 participants

Exposure: MVPA volume quartiles
Outcome: Incident degenerative valvular heart disease (VHD) (AS, aortic valve regurgitation, mitral valve regurgitation)
Follow-up: Median 8.11 years

Main finding

As reported in the abstract

Adjusted AS incidence

Q111.60adjusted rate · 95% CI 10.20–13.20 · per 10 000 person-years

Q27.82adjusted rate · 95% CI 6.63–9.23 · per 10 000 person-years

Q35.74adjusted rate · 95% CI 4.67–7.08 · per 10 000 person-years

Q45.91adjusted rate · 95% CI 4.73–7.39 · per 10 000 person-years

Observational data: associations, not effects.

Secondary outcomes

AS-related intervention or mortality (accelerometer cohort; adjusted rate per 10 000 person-years)

Q1adjusted rate 4.37 per 10 000 person-years95% CI 3.52–5.43

Q4adjusted rate 2.14 per 10 000 person-years95% CI 1.50–3.06

Outcome	adjusted absolute difference (per 10 000 person-years) (CI)
AS incidence and AS-related intervention or mortality (questionnaire-based MVPA) · AS incidence	−1.41 (−.67, −2.14)
AS incidence and AS-related intervention or mortality (questionnaire-based MVPA) · AS-related intervention or mortality	−.38 (−.04, −.88)

AS-related intervention or mortality (accelerometer cohort; adjusted rate per 10 000 person-years): intermediate quartiles: 2.81 (2.13, 3.71) and 1.93 (1.36, 2.75)

AS-related intervention or mortality (accelerometer cohort; adjusted rate per 10 000 person-years)

Steady decline in AS-related intervention or mortality risk with increasing MVPA volume, levelling off beyond approximately 300 min/week

AR and MR incidence

Association of MVPA with AR or MR incidence less apparent

AS, high-risk populations (subgroups)

Beneficial association consistent in patients with hypertension, obesity, dyslipidaemia and CKD

Original publication

Wearable device-measured moderate to vigorous physical activity and risk of degenerative aortic valve stenosis. Eur Heart J. Published 2 July 2024. doi:10.1093/eurheartj/ehae406

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Summarised from the published abstract; every number is checked against it