Acute cardiac care & resuscitation
What is the optimal prehospital blood pressure level after cardiac arrest? A retrospective cohort study on the association of blood pressure and mortality among patients treated with vasoactive medication
Authors' conclusion
Normotension (SBP 100-140 mmHg) was associated with lower mortality compared to hypo- and hypertensive patients. This can be considered a basis for future prospective trials.
Study context
- Population
- Post-resuscitation care cases attended by a Helicopter Emergency Medical Services (HEMS)-physician in which vasoactive treatment was usedpatients with necessary variables recorded, included in primary analysis, 1861 received vasoactive medication of 3029 post-resuscitation cases attended by HEMS
- Participants
- 1,665 participants
- Exposure
- Systolic blood pressure (SBP) categories at handover to hospital compared to hypotensive
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailsmultivariate logistic regression
- Multivariate logistic regression
Main finding
As reported in the abstract
Each group vs SBP < 100 mmHgOdds ratio (CI)
100-119 mmHg
0.54(0.37–0.80)
120-140 mmHg
0.58(0.40–0.85)
> 140 mmHg
0.78(0.51–1.18)
Observational data: associations, not effects.
Further findings
| Outcome | Odds ratio (CI) | |
|---|---|---|
| 1-day mortality100-119 mmHgvs SBP < 100 mmHg | 0.42 (0.28–0.61) | |
| 1-day mortality120-140 mmHgvs SBP < 100 mmHg | 0.42 (0.29–0.61) | |
| 1-day mortality> 140 mmHgvs SBP < 100 mmHg | 0.36 (0.23–0.55) | |
| 0.20.5125Odds ratio (log scale) |
Original publication
What is the optimal prehospital blood pressure level after cardiac arrest? A retrospective cohort study on the association of blood pressure and mortality among patients treated with vasoactive medication. Resuscitation. Published 18 March 2025. doi:10.
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