Prevention & lipidsCohort study
When Does a Calcium Score Equate to Secondary Prevention?
- Cohort study
- multinational registry (CONFIRM)
Authors' conclusion
Patients with CAC scores >300 are at an equivalent risk of MACE and its components as those treated for established ASCVD.
Study context
- Population
- Persons without known CAD and known coronary artery calcium (CAC) scores vs persons with established atherosclerotic cardiovascular disease (ASCVD), multinational CONFIRM registry4,511 without known CAD
- Participants
- 4,949 persons
- Exposure
- No ASCVD history by CAC score vs established ASCVD
- Established ASCVDn = 438reference
- Outcome
- MACE, MACE plus late revascularization, MI and all-cause mortality
- Follow-up
- Median 4 years (IQR: 1.7-5.7 years)
Main finding
As reported in the abstract
MACE by CAC level vs established ASCVD · median follow-up 4 years
All-cause mortality, major adverse cardiovascular events (MACE), MACE + late revascularization and myocardial infarction (MI) not significantly different with CAC >300 vs established ASCVD
all P > 0.05
Observational data: associations, not effects.
Original publication
When Does a Calcium Score Equate to Secondary Prevention? JACC Cardiovasc Imaging. Published 24 May 2023. doi:10.1016/j.jcmg.2023.03.008
Summarised from the published abstract; every number is checked against it