Wide Variation in Reported Rates of Stroke Across Cohorts of Patients With Atrial Fibrillation
Authors' conclusion
Substantial variation exists across cohorts in overall stroke rates and rates corresponding to CHA2DS2-VASc point scores.
Study context
- Population
- Patients with nonvalvular atrial fibrillation (AF) not treated with OAC34 studies
- Outcome
- Reported stroke rates and their relationship to CHA2DS2-VASc scores
Pooled result
As reported in the abstract
Stroke rates across cohorts
- Overall stroke rates in cohort studies highly heterogeneous (Q=5706.54; I2 = 99.6%)
- P<0.001
- Range of overall stroke rates in cohort studies
- 0.45% to 9.28% per year
- Mean North American stroke rate less than one-third of mean European rate
- P<0.0001
- CHA2DS2-VASc 1: cohorts reporting ischemic stroke <1% per year
- 76%
- CHA2DS2-VASc 1: cohorts reporting stroke >2% per year
- 18%
- CHA2DS2-VASc 2: cohorts reporting stroke <1% per year
- 27%
- CHA2DS2-VASc 2: cohorts reporting stroke 1–2% per year
- 40%
- CHA2DS2-VASc 2: cohorts reporting stroke >2% per year
- 33%
Original publication
Wide Variation in Reported Rates of Stroke Across Cohorts of Patients With Atrial Fibrillation. Circulation. Published 31 October 2016. doi:10.
Summarised from the published abstract; every number is checked against it