Heart failure & cardiomyopathiesCross-sectional study
Wild-type transthyretin cardiac amyloidosis is not rare in elderly subjects: the CATCH screening study
- Cross-sectional screening study
- population-based
- general practice
Authors' conclusion
Wild-type transthyretin cardiac amyloidosis is uncommon in elderly subjects from the general population, but more frequent than expected for a rare disease.
Study context
- Population
- Individuals aged 65–90 years from the general population (GP patients, Pisa, Italy)870 completed screening
- Participants
- 1,000 individuals
- Outcome
- Prevalence of ATTRwt-CA
Main finding
As reported in the abstract
Prevalence of ATTR-CA in subjects ≥ 65 years
Prevalence of ATTR-CA (4 of 870 completing screening)
0.46%
Observational data: associations, not effects.
Further findings
Screening cascade
- Individuals with ≥1 red flag
- 346
- Accepted monoclonal protein search and bone scintigraphy
- 216
- Non-invasive diagnosis of ATTRwt-CA
- 4
Characteristics of diagnosed patients
- All complained of dyspnoea on moderate effort
- 2 patients (aged 79 and 85): Grade 3 uptake, left ventricular (LV) wall thickening, Grade 2–3 diastolic dysfunction, NT-proBNP > 1000 ng/L
- 2 patients (aged 74 and 83): Grade 2 uptake, increased LV septal thickness, preserved diastolic function, NT-proBNP < 300 ng/L
Original publication
Wild-type transthyretin cardiac amyloidosis is not rare in elderly subjects: the CATCH screening study. Eur J Prev Cardiol. Published 8 March 2024. doi:10.1093/eurjpc/zwae093
Summarised from the published abstract; every number is checked against it