Prevention & lipidsCohort study
Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts
- Prospective cohort study
- two cohorts
- multivariable-adjusted
Authors' conclusion
In PREDIMED, moderate wine consumption, as part of the MedDiet, appeared to be associated with lower mortality and CVD risk. Some non-significant associations and interactions advise caution in interpretation of these findings.
Study context
- Population
- High-risk participants in PREDIMED; younger Spanish SUN cohortPREDIMED 7447
- Exposure
- Good vs poor Mediterranean diet (MedDiet) compliance, excluding or including wine
- Outcome
- Major CVD or all-cause mortality
- Follow-up
- CVD over 4.8-year ; all-cause mortality over 17 years
Main finding
As reported in the abstract
PREDIMED: CVD and all-cause mortality
Each group vs poor compliersHazard ratio (95% CI)
Good compliers (excluding wine)CVD; multivariable-adjusted
0.84(0.61–1.15)
Good compliers (including wine)CVD
0.55(0.36–0.83)
Good compliers (excluding wine)all-cause mortality
0.77(0.68–0.87)
Good compliers (including wine)all-cause mortality
0.67(0.57–0.78)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| SUN cohort: all-cause mortality — Good compliers (excluding wine) vs Poor compliers | 0.94 (0.71–1.26) | |
| SUN cohort: all-cause mortality — Good compliers (including wine) vs Poor compliers | 0.54 (0.28–1.04) | |
| 0.20.5125Hazard ratio (log scale) |
PREDIMED: exploratory dose-response, abstainer bias and interaction analyses
- Reduced risk of death not present with ≥3 glasses of wine/day
- Analyses least vulnerable to abstainer bias not significant
- Multiplicative interaction terms for the wine item not significant
- exploratory
SUN cohort: Cardiovascular disease (CVD)
- No significant associations between MedDiet compliance, wine and CVD
Pooled cohorts: all-cause mortality
- Wine within the MedDiet associated with lower all-cause mortality
- P = 0.01
Original publication
Wine consumption, Mediterranean diet, and cardiovascular risk in two Spanish cohorts. Eur Heart J. Published 11 February 2026. doi:10.1093/eurheartj/ehaf1081
Summarised from the published abstract; every number is checked against it