Arrhythmias & electrophysiologySecondary analysis
Women with persistent atrial fibrillation need more than pulmonary vein isolation: personalised extra-pulmonary vein ablation strategy vs. pulmonary vein isolation alone in the TAILORED-AF trial
- Secondary analysis of the TAILORED-AF randomised trial
- sex-specific subgroup analysis
Authors' conclusion
Compared to men, PVI-only in women with persistent AF leads to a significantly lower freedom from atrial arrhythmia. A personalised spatio-temporal dispersion-targeted ablation strategy led to a higher rate of freedom from any atrial arrhythmia than standard PVI after a single procedure in women and comparable outcomes between women and men.
Study context
- Population
- Patients with persistent atrial fibrillation (AF) in TAILORED-AF; women (21%) vs men21% female
- Participants
- 370 patients
- Comparison
- Artificial intelligence (AI)-guided tailored ablation vs pulmonary vein isolation (PVI)-only in women with persistent AF
- Primary endpoint
- Single-procedure freedom from AF and from any atrial arrhythmia, women vs men
- Follow-up
- 12 months
Primary result
As reported in the abstract
Single-procedure freedom from AF and any atrial arrhythmia, by sex
- Tailored vs PVI-only: log-rank P < 0.001
- Tailored vs PVI-only: log-rank P < 0.05
- Women vs Men: log-rank P < 0.001
- Women vs Men: log-rank P < 0.001
- Women vs Men: log-rank P = 0.07
- Women vs Men: log-rank P = 0.69
Further findings
Age and AF substrate, women vs men · age
P < 0.001
- Age and AF substrate, women vs men — Left atrial low-voltage surface area (<0.2 mV) significantly larger in women
- P < 0.01
Age and AF substrate, women vs men
- Spatio-temporal dispersion extent similar between groups
Original publication
Women with persistent atrial fibrillation need more than pulmonary vein isolation: personalised extra-pulmonary vein ablation strategy vs. pulmonary vein isolation alone in the TAILORED-AF trial. Europace. Published 28 November 2025. doi:10.1093/europace/euaf281
Summarised from the published abstract; every number is checked against it