Worldwide impact of COVID-19 on hospital admissions for non-ST-elevation acute coronary syndromes (NSTACS): a systematic review with meta-analysis of 553 038 cases
Pooled resultResult — go to the resultIncidence rate ratio 0.70 95% CI 0.66–0.75Authors' conclusion
During the COVID-19 pandemic, NSTACS hospitalizations decreased significantly worldwide. However, substantial heterogeneity emerged among countries, and within the same country.
Study context
- Population
- Hospitalizations for NSTACS, 40 countries102 articles
- Participants
- 553,038 hospitalizations
- Comparison
- COVID-19 pandemic period vs reference period
- Outcome
- IRR of NSTACS hospitalizations vs reference period
- Follow-up
- Peak COVID-19 pandemic
Methodological detailsrandom-effects model, meta-regression
- Random-effects model
- Meta-regression
Pooled result
As reported in the abstract
Incidence rate ratio
0.70
95% CI 0.66–0.75
P < 0.00001
COVID-19 pandemicvs Reference period
IRR 0.70 (95% CI 0.66–0.75); P < 0.00001
Further pooled results
NSTACS hospitalisations, by type of reference period (subgroup)
- Comparing different periods within 2020: greater decrease, IRR
- 0.61 (0.53-0.71) (CI)
- Comparing 2020 vs previous years: IRR
- 0.74 (0.69-0.79) (CI)
NSTACS hospitalisations, by study quality
- No significant differences by study quality
Predictors of heterogeneity (meta-regression)
- Major predictors: SARS-CoV-2 reproduction rate/country, number of hospitals queried, reference period length
- Country stringency index and socio-economical indicators did not contribute significantly
Original publication
Worldwide impact of COVID-19 on hospital admissions for non-ST-elevation acute coronary syndromes (NSTACS): a systematic review with meta-analysis of 553 038 cases. Eur Heart J Qual Care Clin Outcomes. Published 14 August 2023. doi:10.
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