Worsening heart failure events in adults with mild-to-moderate chronic kidney disease
Authors' conclusion
WHF is a common source of morbidity in adults with earlier stage CKD, and particularly high in those with lower eGFR and greater albuminuria.
Study context
- Population
- Adults with mild-to-moderate chronic kidney disease (CKD) (eGFR 30–59 mL/min/1.73m² or eGFR ≥60 mL/min/1.73m² with albuminuria), 2012–20216.5% prior known heart failure (HF)
- Participants
- 375,495 adults
- Outcome
- WHF events:
- Hospitalizations
- ED visits
- Outpatient encounters
Methodological detailslarge integrated healthcare delivery system
- Large integrated healthcare delivery system
Main finding
As reported in the abstract
WHF event rates per 100 person-years
Hospitalizations for worsening HF (WHF), per 100 person-years
1.85
95% CI 1.83–1.87
ED visits for WHF, per 100 person-years
0.85
95% CI 0.84–0.86
Outpatient encounters for WHF, per 100 person-years
0.83
95% CI 0.81–0.84
Cumulative WHF event rate, per 100 person-years
2.42
95% CI 2.40–2.44
Observational data: associations, not effects.
Further findings
WHF event rates by eGFR and albuminuria
- Event rates higher at lower eGFR and higher albuminuria levels
Original publication
Worsening heart failure events in adults with mild-to-moderate chronic kidney disease. Am Heart J. Published 17 October 2025. doi:10.
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