Valvular & structural heart diseaseCohort study
Zipping Versus Clover Repair in Transcatheter Edge-to-Edge Tricuspid Repair: Insights From the TRI-SPA Registry
- multicenter registry
Authors' conclusion
Residual TR was more common in patients treated with the clover technique, owing to the higher prevalence of complex tricuspid valve anatomy. Clinical outcomes were similar between the zipping and clover techniques. Both approaches represent viable and effective treatment options for managing TR.
Study context
- Population
- Patients undergoing tricuspid transcatheter edge-to-edge repair from June 2020 to December 2024patients undergoing tricuspid transcatheter edge-to-edge repair
- Participants
- 288 patients
- Exposure
- zipping and clover repairs
- zippingn = 197
- clovern = 91
- Outcome
- TR reduction (residual TR ≤2+)
- Follow-up
- follow-up
Main finding
As reported in the abstract
P = 0.006
Observational data: associations, not effects.
Secondary outcomes
| Outcome | P value |
|---|---|
| New York Heart Association functional class · without differences | P = 0.835 |
| TR reintervention · 1-year · without differences | P = 0.196 |
Single-leaflet device attachment · follow-up
- Higher with clover technique, attributed to a higher prevalence of complex tricuspid valve anatomy
Composite of all-cause mortality and heart failure hospitalization (secondary end point) · follow-up
- Similar rates among the groups
Follow-up duration
- Median follow-up duration
- 11.6 months (interquartile range, 4.5-21.2)
Original publication
Zipping Versus Clover Repair in Transcatheter Edge-to-Edge Tricuspid Repair: Insights From the TRI-SPA Registry. Circ Cardiovasc Interv. Published 20 January 2026. doi:10.1161/circinterventions.125.015771
Summarised from the published abstract; every number is checked against it