Acute cardiac care & resuscitation
3-Dimensional quantification of ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury
Authors' conclusion
We present a robust, observer-independent workflow for anatomically resolved quantification of ischemic injury in HIBI. Atlas-based segmentation integrated with voxel-intensity ADC analysis, enabled generation of granular data on the pattern and extent of ischemic brain injury following cardiac arrest.
Study context
- Population
- Post-cardiac arrest patients with hypoxic-ischemic brain injury (HIBI)
- Participants
- 10 patients
- Exposure
- White matter vs Gray matter
- Outcome
- Spatial distribution of ischemic injury
Methodological detailssemi-automated analysis pipeline
- Semi-automated analysis pipeline
Main finding
As reported in the abstract
- Spatially heterogeneous but consistently affected the putamen, thalamus, and posterior cortical regions (e.g., pericalcarine and perirolandic cortices)
Observational data: associations, not effects.
Further findings
Relative lesion volume (% of total brain volume) · greater involvement in white matter
P = 0.005
- Relative lesion volume (% of total brain volume) — Overall mean relative lesion volume
- 28.4 ± 14.1%
Overlap of susceptibility-weighted imaging (SWI) and apparent diffusion coefficient (ADC) hypointensities
- Overlap of SWI and ADC hypointensities
- <1% of all voxels
- Indicating negligible confounding by intraparenchymal blood
Original publication
3-Dimensional quantification of ischemic brain injury in post-cardiac arrest patients with hypoxic-ischemic brain injury. Resuscitation. Published 10 March 2026. doi:10.
Summarised from the published abstract; every number is checked against it