Valvular & structural heart disease
3D Echocardiographic and CMR Imaging for the Assessment of Right Ventricular Function and Tricuspid Regurgitation Severity
Authors' conclusion
3DE provides an accurate assessment of TR severity comparable to CMR. The proposed 5-class grading scheme for TR severity using CMR demonstrates high accuracy and external validity.
Study context
- Population
- Patients with symptomatic tricuspid regurgitation (TR)patients with symptomatic TR analyzed across 2 cohorts · derivation cohort (University Hospital of Munich) 91 · validation cohort (Heart Center Leipzig) 53
- Participants
- 144 patients
- Comparison
- Intermodality comparison of all 3 imaging modalities (2DE, 3DE, and CMR) in evaluating TR severity
- Outcome
- TR severity grading concordance with CMR within a 1-grade difference
Methodological detailsderivation cohort and external validation cohort, multimodality imaging, 2 centres
- Derivation cohort and external validation cohort
- Multimodality imaging
- 2 centres
Performance
As reported in the abstract
Further findings
| Outcome | 2DE | 3DE | P value |
|---|---|---|---|
| Accuracy of 2DE compared with CMRFrequent overestimation of TR severity | accuracy 34.5% | — not stated in the abstract | |
| Overestimation of TR severity compared with CMR3DE vs 2DE · significantly less frequent with 3DE | 56% | 21% | P < 0.001 |
| Cohen κ agreement with CMR3DE vs 2DE · superior agreement with 3DE | 0.41 | 0.63 | P = 0.01 |
— not stated in the abstract
- Right ventricular dimensions, 3DE vs CMR
- P < 0.001
- Right ventricular dimensions, 3DE vs CMR: 3DE underestimated right ventricular dimensions compared with CMR
- Accuracy of 2DE compared with CMR: P =0.005
Right ventricular dimensions, 3DE vs CMR
- 3DE provided a comparable measure of TR severity and right ventricular function
External validation
- Comparable results within the derivation and validation cohorts
Original publication
3D Echocardiographic and CMR Imaging for the Assessment of Right Ventricular Function and Tricuspid Regurgitation Severity. Circ Cardiovasc Imaging. Published 21 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →