Valvular & structural heart disease
Computed tomography calcium scoring in aortic stenosis: bicuspid versus tricuspid morphology
Authors' conclusion
Valve calcification in AS differs according to valve morphology and sex. BAV-men with severe AS exhibit greater AVCscore and AVCdensity than TAV-men.
Study context
- Population
- Patients referred for clinical aortic stenosis (AS) evaluation with echocardiographic AS severity and CT-AVC assessments within 6 months, LVEF ≥50%
- Participants
- 1,957 patients
- Exposure
- Bicuspid aortic valve (BAV) vs tricuspid aortic valve (TAV)
- BAVn = 328
- TAVn = 1,629reference
- Outcome
- CT aortic valve calcium score (AVCscore) and density (AVCdensity), Agatston method
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- BAV associated with higher aortic valve calcium score (AVCscore) and AVCdensity independent of age, comorbidities and AS severity, in men only
- p<0.001
- Sex and BAV interaction
- p<0.001
Observational data: associations, not effects.
Further findings
Baseline characteristics
Men BAV 65% · TAV 56%
- Baseline characteristics — Age difference
- p<0.001
- Baseline characteristics — Sex difference
- p=0.006
AVCscore and AVCdensity in severe AS, by sex (subgroup)
- Higher in BAV-men than TAV-men
- both p<0.001
- Similar in BAV-women and TAV-women
- both p≥0.4
- Patterns unchanged after adjustment for clinical covariates and AS severity
Best thresholds for severe AS diagnosis in BAV
- BAV-men AVCscore (higher than guideline-recommended)
- 2916 AU
- BAV-men AVCdensity (higher than guideline-recommended)
- 600 AU/cm²
- BAV-women AVCscore (similar to guideline-recommended)
- 1036 AU
- BAV-women AVCdensity (similar to guideline-recommended)
- 282 AU/cm²
Original publication
Computed tomography calcium scoring in aortic stenosis: bicuspid versus tricuspid morphology. Heart. Published 30 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →