Valvular & structural heart disease
5-Year Outcomes of Anterior Mitral Leaflet Laceration to Prevent Outflow Obstruction
Authors' conclusion
LAMPOON enabled TMVR despite the risk for LVOT obstruction. There were no long-term complications associated with LAMPOON.
Study context
- Population
- Patients undergoing SAPIEN 3 transcatheter mitral valve replacement (TMVR) at high predicted risk of left ventricular outflow tract (LVOT) obstruction; not excluded for excessive frailty or comorbidityenrolled June 2017–June 2018
- Participants
- 30 patients
- Exposure
- valve-in-MAC vs valve-in-ring
- Outcome
- Technical success and safety
- Follow-up
- 30 days
Methodological details5-year follow-up, multicentre
- 5-year follow-up
- Multicentre
Main finding
As reported in the abstract
LAMPOON successful
30 of 30 subjects
Strokes
0
Death
1
3%
Moderate LVOT obstruction
1
3%
Observational data: associations, not effects.
Further findings
Survival · 1 year
- Survived to 1 year
- 18 (65%)
Survival · 5 years
- Survived to 5 years
- 7 (25%)
HF hospitalisation · first year
- Hospitalised for HF
- 6 (20%)
KCCQ score and 6-minute walk distance, baseline to 1 year
- Improvement in KCCQ score
- 24-point
- Improvement in 6-minute walk distance
- 60-m
NT-proBNP · 1 year
- No significant change in NT-proBNP
LVOT gradients · 1 year
- LVOT gradients remained low
Safety
30-day safety
- Strokes
- 0
- Death
- 1 (3%)
- Moderate LVOT obstruction
- 1 (3%)
Original publication
5-Year Outcomes of Anterior Mitral Leaflet Laceration to Prevent Outflow Obstruction. JACC Cardiovasc Interv. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →