[ 99m Tc]-PentixaTec Single-photon Emission Computed Tomography (SPECT)/CT for Imaging of Chemokine Receptor 4 Expression After Myocardial Infarction
Authors' conclusion
Increased CXCR4 expression was observed locally in the infarcted region and was related to a systemic inflammatory response in the reticuloendothelial system.
Study context
- Population
- Patients with acute myocardial infarction (AMI) after mechanical revascularization
- Participants
- 9 patients
- Outcome
- CXCR4 expression after AMI on [99mTc]-PentixaTec SPECT/CT
Main finding
As reported in the abstract
CXCR4-directed SPECT positive in all patients
9
Signal-to-background ratio (infarcted area-to-blood pool), only in areas with diminished perfusion of the affected vessel
2.36±0.74
Correlation of spleen uptake with infarct CXCR4 expression
r=0.73
P=0.03
Correlation of bone marrow uptake with infarct CXCR4 expression
r=0.81
P=0.008
Observational data: associations, not effects.
Further findings
Correlation of spleen and bone marrow uptake with infarct CXCR4 expression
- Spleen
- r=0.73, P=0.03
- Bone marrow
- r=0.81, P=0.008
Association of SPECT inflammatory changes with serum troponin, CK, leukocytes, CRP
- No significant association
Original publication
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