Heart failure & cardiomyopathiesCohort study
A high proportion of children with severe cardiomyopathies show both myocarditis and genetic predispositions
- Retrospective cohort study
Authors' conclusion
In severe CMPY, genetic causes and myocarditis because of infection are common. About 50% of childhood cardiomyopathies are linked to pathogenic genetic variants.
Study context
- Population
- Children and adolescents with severe cardiomyopathy requiring HTx, mechanical circulatory support (MCS) or any in-hospital treatmentindex patients genotyped
- Participants
- 106 children
- Exposure
- Myocarditis vs No myocarditis
- Myocarditisn = 57
- No myocarditisn = 27
- Outcome
- Genetic profile and prevalence of myocarditis
Main finding
As reported in the abstract
P/LP variant and myocarditis prevalence
Carried a (likely) pathogenic (P/LP) variant
54 (51%)
Myocarditis among 84 examined
57 (68%)
Chronic lymphocytic myocarditis
34 (40%)
Observational data: associations, not effects.
Further findings
P/LP variants by myocarditis status
Dilated cardiomyopathy
- Dilated cardiomyopathy
- 87 (82%)
De novo P/LP variants suggested by parental genotyping
- Cases with parental genotyping suggesting de novo P/LP variants
- 41 (39%)
- de novo P/LP-variants (34%)
Original publication
A high proportion of children with severe cardiomyopathies show both myocarditis and genetic predispositions. Eur J Heart Fail. Published 3 July 2026. doi:10.1093/ejhf/xuag214
Summarised from the published abstract; every number is checked against it