Heart failure & cardiomyopathies
Sex differences in early ventricular fibrillation among patients with fulminant myocarditis in a nationwide registry
Main finding · VFResult — go to the resultSubdistribution hazard ratio 1.58 95% CI 1.09–2.28Authors' conclusion
In a nationwide registry of fulminant myocarditis, female sex was associated with a higher risk of early VF, whereas there was no clear evidence of a sex difference in 90-day all-cause mortality. Incorporating sex into early risk assessment may help tailor acute monitoring and management strategies in this high-risk condition.
Study context
- Population
- Patients with fulminant myocarditis (prodromal symptoms within 4 weeks and need for catecholamines and/or mechanical circulatory support within 14 days of admission) in a Japanese nationwide registry40% female
- Participants
- 696 patients
- Exposure
- Female vs male sex and 30-day ventricular fibrillation (VF)
- Outcome
- VF
- Follow-up
- Within 30 days after admission
Methodological detailsJapanese Registry of Fulminant Myocarditis, 2012–2017, Fine-Gray competing-risk regression (death as the competing event)
- Japanese Registry of Fulminant Myocarditis
- 2012–2017
- Fine-Gray competing-risk regression (death as the competing event)
Main finding
As reported in the abstract
Subdistribution hazard ratio
1.58
95% CI 1.09–2.28
P = 0.016
By group
Female patientsvs Male patients
subdistribution HR 1.58 (95% CI 1.09–2.28); P = 0.016
- VF within 30 days, all patients
- 120 (17%)
Observational data: associations, not effects.
Further findings
All-cause mortality · 90 days
P = 0.732
Original publication
Sex differences in early ventricular fibrillation among patients with fulminant myocarditis in a nationwide registry. Heart. Published 21 September 2026. doi:10.
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