Congenital heart diseaseCohort study

A Knowledge Graph Framework for Longitudinal Congenital Heart Disease Modeling

JACC AdvPublished

  • knowledge graph-based framework
  • longitudinal knowledge graph
  • Term frequency-inverse document frequency and Word2Vec approaches

Authors' conclusion

This knowledge graph framework provides a scalable approach for preserving temporal and relational clinical context and enable trajectory-aware modeling of longitudinal cardiovascular EHR data in patients with CHD.

Study context

Population
Patients with congenital heart disease (CHD) in a cardiovascular magnetic resonance cohort, longitudinal electronic health record (EHR) data

Main finding

As reported in the abstract

Retrospective identification of single ventricle physiology and capture of clinically meaningful patterns
  • the framework captured clinically meaningful patterns and supported retrospective identification of single ventricle physiology as a representative use case

Observational data: associations, not effects.

Original publication

A Knowledge Graph Framework for Longitudinal Congenital Heart Disease Modeling. JACC Adv. Published 3 October 2026. doi:10.1016/j.jacadv.2026.103291

Summarised from the published abstract; every number is checked against it