Valvular & structural heart disease
A Novel Hemodynamic Index Characterizing Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair: The MPF
Authors' conclusion
MPF could provide an immediate estimate of the real hemodynamic impact of MR and a prompt prediction of the functional improvement after TEER.
Study context
- Population
- Patients with moderate-to-severe or severe mitral regurgitation (MR)
- Participants
- 78 vs 23
- Exposure
- Transcatheter edge-to-edge repair (TEER) vs control
- TEERn = 78
- Controln = 23reference
- Outcome
- Mitral pulse pressure fraction (MPF) from intraprocedural continuous left atrial pressure monitoring
- Follow-up
- Post-TEER
Main finding
As reported in the abstract
- Post-TEER MPF significantly reduced vs pre-TEER
- P < 0.001
- Post-TEER MPF significantly reduced vs control
- P < 0.001
Observational data: associations, not effects.
Further findings
Functional status at follow-up (NYHA, 12-item Kansas City Cardiomyopathy Questionnaire (KCCQ))
- Greater MPF reduction associated with improved NYHA class
- P = 0.036
- Greater MPF reduction associated with improved 12-item KCCQ
- P = 0.032
- MR reduction by transesophageal echocardiographic (TEE) associated with improved 12-item KCCQ but not NYHA class
- Reassessed in the majority of TEER patients
Original publication
A Novel Hemodynamic Index Characterizing Mitral Regurgitation Undergoing Transcatheter Edge-to-Edge Repair: The MPF. JACC Adv. Published 13 July 2024. doi:10.
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