Valvular & structural heart disease
Predictors and clinical impact of worsening left ventricular ejection fraction after mitral transcatheter edge-to-edge repair
Authors' conclusion
LVEF worsening after TEER was not uncommon and was caused by the increased LVESV. LV volumes and some patient-specific factors predicted worsened LVEF which was not associated with long-term clinical outcomes.
Study context
- Population
- Patients with primary or secondary mitral regurgitation (MR) undergoing successful TEER (postprocedural MR grade ≤2+)493 primary MR (PMR), 1,526 secondary MR (SMR)
- Participants
- 2,019 patients
- Exposure
- Worsened left ventricular ejection fraction (LVEF) vs preserved LVEF after TEER
- wEFn = 657
- Outcome
- Incidence of wEF after TEER
- Follow-up
- Discharge
Methodological detailsOCEAN-Mitral registry
- OCEAN-Mitral registry
Main finding
As reported in the abstract
wEF
32%
657
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Death or HF hospitalisationAlso in PMR and SMR | 1.14 (0.72–1.80) | P = 0.84 | |
| 0.512Hazard ratio (log scale) |
LVEF in wEF, baseline to 1 year
- LVEF 46% to 43%
- P < 0.001
Stroke volume in wEF, baseline to 1 year
- Stroke volume 48 mL to 53 mL (significant increase)
- P = 0.001
Original publication
Predictors and clinical impact of worsening left ventricular ejection fraction after mitral transcatheter edge-to-edge repair. EuroIntervention. Published 18 November 2024. doi:10.
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