Heart failure & cardiomyopathies
A Prospective Analysis of Management and Outcomes of Worsening Heart Failure in the Outpatient Setting
Authors' conclusion
Outpatient WHF was successfully treated in the majority of patients in the community. However, despite initial stabilisation, there is a persistent risk of recurrent deterioration.
Study context
- Population
- Patients treated for outpatient worsening HF (WHF) requiring diuretic escalation, ambulatory HF clinic, August 2022 to March 2024
- Participants
- 234 patients
- Exposure
- Bailout therapies vs Oral loop diuretic only
- Bailout therapiesn = 106
- Oral loop diuretic onlyn = 128reference
- Outcome
- Outcomes of the presenting WHF episode
Methodological detailsconsecutive patients, single ambulatory HF clinic
- Consecutive patients
- Single ambulatory HF clinic
Main finding
As reported in the abstract
Outcome of presenting WHF episode
- Stabilisation achieved
- 78.6% (184)
- HF hospitalisation
- 16.2% (38)
- Non-HF-related admissions
- 3.4% (8)
- Died without hospitalisation
- 2 (0.9%)
- Requested follow-up in other units
- 2 (0.9%)
Observational data: associations, not effects.
Further findings
Adverse clinical outcomes by treatment
OR 7.24 · P < 0.001
- Adverse clinical outcomes by treatment — Bailout therapies used
- 45.3% (106)
Recurrence among initially stabilised (n=184) · subsequent 3 months
- Recurrent outpatient WHF
- 24.5% (45/184)
- HF hospitalisation
- 4.9% (9/184)
Original publication
A Prospective Analysis of Management and Outcomes of Worsening Heart Failure in the Outpatient Setting. ESC Heart Fail. Published 28 August 2025. doi:10.
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