A randomised trial of selective intracoronary hypothermia during primary percutaneous coronary intervention (PCI)
Authors' conclusion
Selective intracoronary hypothermia during primary PCI in patients with anterior wall STEMI was feasible and safe but did not decrease infarct size compared with standard primary PCI.
Study context
- Population
- Patients with large anterior wall ST-elevation myocardial infarction (STEMI) undergoing primary PCIrandomised 1:1
- Participants
- 200 patients
- Comparison
- Selective intracoronary hypothermia vs Primary PCI alone
- Primary endpoint
- Infarct size as % of LV mass on CMR
- Follow-up
- 3 months
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Infarct size (% of LV mass)
P = 0.43
Further findings
LVEF · 3 months
P = 0.53
| Outcome | Selective intracoronary hypothermia | Primary PCI alone | |
|---|---|---|---|
| Procedural feasibility (hypothermia group) | |||
| Hypothermia performed | 94/100 | Not reported in the abstract | Primary PCI alone: not reported in the abstract |
| Time to 6°C decrease in distal coronary temperature | 43 seconds (IQR 18-113) | Not reported in the abstract | Primary PCI alone: not reported in the abstract |
| Median occlusion phase duration | 8.2 minutes (IQR 7.2-9.0) | Not reported in the abstract | Primary PCI alone: not reported in the abstract |
| Median reperfusion phase duration | 9.1 minutes (IQR 8.2-10.0) | Not reported in the abstract | Primary PCI alone: not reported in the abstract |
Original publication
A randomised trial of selective intracoronary hypothermia during primary PCI. EuroIntervention. Published 17 June 2024. doi:10.
Summarised from the published abstract; every number is checked against it