Acute cardiac care & resuscitation
A single center experience and outcomes with central and peripheral cannulations for paediatric extracorporeal cardiopulmonary resuscitation
Main finding · SurvivalResult — go to the resultAdjusted odds ratio 0.95 95% CI 0.92–0.99Authors' conclusion
In paediatric ECPR, total resuscitation duration remains a key metric associated with patient outcomes. In this single-center study, open peripheral cannulation is associated with more difficult and failed attempts compared to central cannulation.
Study context
- Population
- Patients < 18 years with in-hospital extracorporeal cardiopulmonary resuscitation (ECPR) events from 2015 to 2020ECPR events meeting eligibility criteria
- Participants
- 92 patients
- Exposure
- Central vs peripheral cannulation approaches; total resuscitation duration (CPA-ECMO) and survival
- Centraln = 40
- Peripheraln = 52
- Outcome
- Survival
- Follow-up
- Hospital discharge
Main finding
As reported in the abstract
Adjusted odds ratio
0.95
95% CI 0.92–0.99
P = 0.023
Total resuscitation duration (CPA-ECMO)
adjusted OR 0.95 (95% CI 0.92–0.99); P = 0.023
Observational data: associations, not effects.
Secondary outcomes
Favourable neurologic outcome (secondary) · hospital discharge
| Adjusted OR (95% CI) | P value | ||
|---|---|---|---|
| Total resuscitation duration (CPA-ECMO) | 0.95 (0.92–0.99) | P = 0.030 | |
| 0.512Adjusted odds ratio (log scale) |
Difficult cannulation
Total resuscitation duration, arrest to ECMO flow initiation (CPA-ECMO)
P = 0.12
- Favourable neurologic outcome (secondary): adjusted for cannulation approach, precipitating event, initial shockable rhythm, and location of cannulation
Patient characteristics
- Median age
- 4 months (IQR 1 month, 16 years)
- Weight
- 4.4 kg (range 1.9-133 kg)
- Central cannulation
- 43% (40/92)
ECMO flows achieved
- ECMO flows achieved
- 91% (84/92)
- Failure to achieve flows, exclusively with peripheral attempts
- N = 8/52
Original publication
A single center experience and outcomes with central and peripheral cannulations for paediatric extracorporeal cardiopulmonary resuscitation. Resuscitation. Published 13 June 2025. doi:10.
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