Heart failure & cardiomyopathies
Ablation of Ventricular Preexcitation to Cure Preexcitation-Induced Dilated Cardiomyopathy in Infants: Diagnosis and Outcome
Authors' conclusion
Ventricular preexcitation could lead to severe cardiac dysfunction during infancy. RFCA may be a safe and effective treatment option in right free wall accessory pathways, even in infants with cardiac dysfunction. Cases of more severe cardiac dysfunction might require a longer time for LVEF recovery after RFCA.
Study context
- Population
- Infants with preexcitation-induced dilated cardiomyopathy refractory to drugs (mean age 6.78±3.14 months; mean left ventricular ejection fraction (LVEF) 32.6±10.34%)4 males · 6 females
- Participants
- 10 infants
- Outcome
- Acute ablation success
Main finding
As reported in the abstract
Radiofrequency ablation (RFCA)
100%
- Recurrence of preexcitation, ablated successfully at second attempt
- 1
Observational data: associations, not effects.
Further findings
Time to LVEF normalization by baseline dysfunction
- Mild (40≤LVEF<50%), n = 3
- 1 week
- Moderate (30≤LVEF<40%), n = 3
- 1 to 3 months
- Severe (LVEF<30%), n = 4
- ≥3 months
- Severe: LVEF normalized after ablation in 3 of 4 (at 3, 6 and 12 months); 1 not recovered at 3 months, still followed
Safety
Procedure-related complications
- No complication associated with the procedure occurred
- All 10 patients underwent RFCA
Recurrence of preexcitation
- Preexcitation recurred, ablated successfully at second attempt
- 1
Original publication
Ablation of Ventricular Preexcitation to Cure Preexcitation-Induced Dilated Cardiomyopathy in Infants: Diagnosis and Outcome. Circ Arrhythm Electrophysiol. Published 9 March 2023. doi:10.
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