Heart failure & cardiomyopathies
Dyssynchrony and Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Unfavorable Electrical Characteristics
Authors' conclusion
In patients with UEC, echocardiographic assessment of EMD may help to select patients who will derive benefit from CRT.
Study context
- Population
- Heart failure (HF) patients receiving cardiac resynchronization therapy (CRT) with unfavorable electrical characteristics (atypical LBBB, RBBB or unspecified intraventricular conduction disturbance)of 551 receiving CRT
- Participants
- 121 patients
- Exposure
- Echocardiographic electromechanical dyssynchrony (EMD) indices vs CRT response and outcome
- Outcome
- CRT response (relative decrease in LV end-systolic volume ≥15%); all-cause death or HF hospitalization
- Follow-up
- 9-month (response)
Main finding
As reported in the abstract
CRT response · 9 months
Adjusted odds ratio (95% CI)P value
GWW ≥200 mm Hg%
4.17(1.33–14.56)
P = 0.0182Longitudinal strain septal contraction patterns 1 and 2
10.05(2.82–43.97)
P < 0.001- CRT responders
- 68 (56%)
Observational data: associations, not effects.
Further findings
Death or HF hospitalization, by number of positive EMD criteria · 46-month follow-up (IQR: 42-55 months)
| 2 criteria | 1 criterion | 0 criteria | Adjusted HR (95% CI) | P value | ||
|---|---|---|---|---|---|---|
| Absence of either of the 2 criteriaAdjusted for established predictors of outcome after CRT | 87% | 59% | 27% | 4.83 (1.84–12.68) | P = 0.001 | |
| 0.050.21520Adjusted hazard ratio (log scale) |
- Death or HF hospitalization, by number of positive EMD criteria: per-group values = survival free from death or HF hospitalization
Original publication
Dyssynchrony and Response to Cardiac Resynchronization Therapy in Heart Failure Patients With Unfavorable Electrical Characteristics. JACC Cardiovasc Imaging. Published 8 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →