Arrhythmias & electrophysiology
Abnormal Conduction Zone Detected by Isochronal Late Activation Mapping Accurately Identifies the Potential Atrial Substrate and Predicts the Atrial Fibrillation Ablation Outcome After Pulmonary Vein Isolation
Main finding · AF recurrenceResult — go to the resultHazard ratio 9.41 95% CI 2.61–33.90Authors' conclusion
Deceleration zone detected by isochronal late activation mapping represents a critical AF substrate, it accurately predicts the AF recurrence following ablation in patients with paroxysmal AF.
Study context
- Population
- Paroxysmal atrial fibrillation (AF) patients undergoing pulmonary vein isolation30 males
- Participants
- 45 patients
- Exposure
- DZb in W2 vs No DZb in W2
- Outcome
- Any recurrence of atrial arrhythmias after a 3-month blanking period
- Follow-up
- Mean 12.7±4.5 months
Methodological details2 patients (4.4%) received additional extrapulmonary vein ablation
- 2 patients (4.4%) received additional extrapulmonary vein ablation
Main finding
AF recurrence
Hazard ratio
9.41
95% CI 2.61–33.90
P < 0.0001
DZb in W2 vs No DZb in W2
HR 9.41 (95% CI 2.61–33.90); P < 0.0001
As reported in the abstract
- AF recurrence, all patients
- 14 patients (31.1%)
Observational data: associations, not effects.
Further findings
Location of DZb in W2 vs low-voltage zone (≤0.5 mV)
- DZb locations matching low-voltage zone
- 52.6%
- DZb in areas without low-voltage zone
- 47.4%
Original publication
Abnormal Conduction Zone Detected by Isochronal Late Activation Mapping Accurately Identifies the Potential Atrial Substrate and Predicts the Atrial Fibrillation Ablation Outcome After Pulmonary Vein Isolation. Circ Arrhythm Electrophysiol. Published 23 January 2023. doi:10.
Summarised from the published abstract; every number is checked against it