Heart failure & cardiomyopathies
Absence of Fibrosis Influences Prognosis of Cardiac Resynchronization in Nonischemic Cardiomyopathy: Systematic Review and Meta-Analysis
Pooled result · Echocardiographic CRT responseResult — go to the resultOdds ratio 3.52 95% CI 2.54–4.88Authors' conclusion
In NICM patients undergoing CRT, the absence of LGE is strongly associated with greater echocardiographic response and very low arrhythmic risk. In this subgroup the incremental benefit of CRT with defibrillator over CRT-P may be limited.
Study context
- Population
- Patients with nonischemic cardiomyopathy (NICM) who underwent cardiac magnetic resonance before cardiac resynchronization therapy (CRT) implantationTen studies included · CRT response (9 studies) 831 · arrhythmic risk (6 studies) 745
- Comparison
- patients without late gadolinium enhancement (LGE) vs patients with LGE
Methodological detailsobservational studies, cardiac magnetic resonance before CRT implantation
- Observational studies
- Cardiac magnetic resonance before CRT implantation
Pooled result
Echocardiographic CRT response
Odds ratio
3.52
95% CI 2.54–4.88
P < 0.001
By group
Patients without LGE vs patients with LGE
OR 3.52 (95% CI 2.54–4.88); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Ventricular arrhythmia (sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator therapy, resuscitated cardiac arrest, sudden death) · absence of LGE associated with much lower arrhythmic risk | 0.06 (0.02–0.15) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Cumulative incidence
| Outcome | Patients without LGE | Patients with LGE | Estimate | P value |
|---|---|---|---|---|
| Ventricular arrhythmia (sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator therapy, resuscitated cardiac arrest, sudden death) · significantly lower in LGE cases than LGE+ ones | 0.8% | 21.1% | P < 0.001 |
- Ventricular arrhythmia (sustained ventricular tachycardia, appropriate implantable cardioverter-defibrillator therapy, resuscitated cardiac arrest, sudden death): abstract labels the groups 'LGE cases' vs 'LGE+ ones' for this result
Original publication
Absence of Fibrosis Influences Prognosis of Cardiac Resynchronization in Nonischemic Cardiomyopathy: Systematic Review and Meta-Analysis. JACC Adv. Published 1 October 2026. doi:10.
Summarised from the published abstract; every number is checked against it