Heart failure & cardiomyopathies
Very Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Ischemic and Nonischemic Cardiomyopathy
Authors' conclusion
Our data suggest that over the very long term (>10 years), patients with NICM had significantly higher survival post-CRT than patients with ischemic cardiomyopathy.
Study context
- Population
- Patients with ejection fraction (EF) ≤35%, QRS ≥120 ms who underwent CRT-D at the Mayo Clinic between January 2001 and September 2022matched cohort
- Participants
- 610 patients
- Exposure
- Nonischemic cardiomyopathy (NICM) vs ischemic cardiomyopathy after CRT-D
- Outcome
- All-cause mortality
Methodological detailssingle-centre (Mayo Clinic), propensity-matched, accelerated failure models with a log-logistic distribution
- Single-centre (Mayo Clinic)
- Propensity-matched
- Accelerated failure models with a log-logistic distribution
Main finding
As reported in the abstract
TR
1.92
P < 0.001
univariate; increased survival with NICM
TR
1.43
P = 0.014
multivariable; increased survival with NICM
Observational data: associations, not effects.
Further findings
Other independent predictors of increased survival post-CRT
- Baseline left bundle branch block morphology, decreasing age, higher left ventricular EF, female gender, and absence of the following comorbidities: atrial fibrillation, type 2 diabetes mellitus, and chronic kidney disease 3 or higher
Original publication
Very Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Ischemic and Nonischemic Cardiomyopathy. JACC Adv. Published 25 April 2025. doi:10.
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