Aortic & peripheral vascular disease
ACADM-mediated fatty acid β-oxidation pathway in atherosclerosis and abdominal aortic aneurysm
Authors' conclusion
These findings define previously unrecognized distinct lipid metabolic characteristics in the pathogenesis of AS vs AAA, providing a basis for differential diagnosis and targeted treatments.
Study context
- Population
- Mouse models of atherosclerosis (AS) and abdominal aortic aneurysm (AAA) and different human cohorts, incl. UK Biobank
- Comparison
- AS vs AAA
- Outcome
- Lipid metabolic differences between AS and AAA
Methodological detailslipidomic analysis, multi-omics, mouse models and human cohorts, machine learning
- Lipidomic analysis
- Multi-omics
- Mouse models and human cohorts
- Machine learning
Main finding
As reported in the abstract
- Predominant enrichment of neutral lipids (e.g. TG and cholesterol esters) in AS vs phosphoglycerides in AAA
- UK Biobank: strong positive associations of TG, cholesterol and fatty acid with future risk of coronary atherosclerotic disease; phosphoglycerides negatively associated with risk of AAA
- Acadm-mediated fatty acid β-oxidation (FAO) pathway the most significantly altered lipid metabolic pathway between AS and AAA
- Targeted restoration of Acadm-mediated FAO inhibited AS (reduced lipotoxic metabolites, preserved mitochondrial homeostasis); little impact on AAA
- LD·ATTEC significantly alleviated AS progression and improved FAO; no significant change in AAA
- Machine learning models on lipidomic features accurately differentiated AS from AAA
Original publication
ACADM-mediated fatty acid β-oxidation pathway in atherosclerosis and abdominal aortic aneurysm. Eur Heart J. Published 5 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →