Aortic & peripheral vascular disease
Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis
Authors' conclusion
Together, these results suggest that GM3 dysregulation promotes ferroptosis of vascular SMCs in AAA.
Study context
- Population
- Patients with abdominal aortic aneurysm (AAA) and AAA mouse models
Main finding
As reported in the abstract
- Significantly reduced plasma GM3 levels in patients with AAA
- GM3 content and ST3GAL5 expression decreased in abdominal aortic vascular smooth muscle cells (SMCs) in patients with AAA and an AAA mouse model
- ST3GAL5 silencing in human aortic SMCs induced ferroptosis (RNA sequencing)
- GM3 interacted directly with the extracellular domain of TFR1 and disrupted its interaction with holo-transferrin
- SMC-specific St3gal5 knockout exacerbated iron accumulation at lesion sites and significantly promoted AAA development in mice
- GM3 supplementation suppressed lipid peroxidation, reduced iron deposition in aortic vascular SMCs and markedly decreased AAA incidence in mice
Original publication
Ganglioside GM3 Protects Against Abdominal Aortic Aneurysm by Suppressing Ferroptosis. Circulation. Published 29 November 2023. doi:10.
Summarised from the published abstract; every number is checked against it